Carpal tunnel syndrome is a condition in which the median nerve is compressed at the wrist in the tunnel formed by the carpal bones and the transverse carpal ligament. The carpal tunnel contains the median nerve and several flexor tendons of the fingers and thumb. Various factors can cause an increase in pressure in the carpal tunnel, resulting in irritation of the median nerve. Carpal tunnel is also sometimes associated with “double crush syndrome,” in which a proximal trauma (neck, shoulder, or elbow) renders the distal nerve (wrist) vulnerable.